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Laser Assisted Hatching

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Laser Assisted Hatching

An essential stage of implantation is hatching. Embryos are usually protected by an outer covering or shell called the Zona pellucida. The zona thins at the time of implantation, allowing the embryo to emerge from its shell and attach to the womb. The failure of the embryos to emerge from the egg could be one of the causes of recurring IVF failure.

What exactly is Assisted Hatching?

The Zona pellucida's outer shell must be thinned or a hole should be drilled in order to facilitate assisted hatching. In the early stages of embryo development (on day 3), when they are in the 6-8 cell stage, or on day 5 when they are in the blastocyst stage, it is carried out prior to embryo transfer.

Methods of Assisted Hatching

  • Mechanical
  • Chemical (Acid Tyrode)
  • Enzyme (Pronase)
  • Laser

When is LAH (Laser Assisted Hatching) advised?

The following are the most typical reasons for recommending a LAH procedure

  • Advanced maternal age (>37 years old)
  • Patients with elevated Day 3 follicle stimulating hormone (FSH)
  • Thick and/or abnormal egg shell
  • Poor quality/slow developing embryos
  • Embryos exhibiting excessive fragmentation
  • Patient with 2 or more previous failed IVF cycles
  • Frozen Thaw Embryo Transfer cycles

Benefits of laser-assisted hatching

Due to a number of benefits, laser assisted hatching has been demonstrated to be superior to chemical and manual assisted hatching.

  • Nominal handling of the embryo
  • Fast and precise control over drilling of the shell opening
  • It is gentle and safe, with no negative effects on the embryo
  • Poor quality/slow developing embryos
  • Wide availability to patients, and offered under clinical guidance depending on your particular circumstances

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